Charles Brenner is the Chair of the new Department of Diabetes & Cancer Metabolism at the Beckman Research Institute of the City of Hope National Medical Center, and Chief Scientific Adviser for ChromaDex. He is a major contributor to work on nicotinamide adenine dinucleotide metabolism, and discovered the eukaryotic nicotinamide riboside (NR) kinase pathway.

What you'll learn from this episode:

  • What are nucleotides, and why is it important to understand how they work if we want to optimize our health and fend off the metabolic stress of disease and aging?

  • How ATP and ADP work together to drive the cellular machinery that makes life possible.

  • The four forms of NAD (NAD+, NADH, NADP+, NADPH) and their functions.

  • Does supplementing with NAD to boost anabolic processes in your body put you at risk for undesirable consequences like tumor growth?

  • What sets the different types of vitamin B3s (niacin, nicotinamide, and nicotinamide riboside [NR]) apart.

  • And so much more!

This episode is sponsored by my friends at Tru Niagen. Elevate your NAD+ (nicotinamide adenine dinucleotide) with Tru Niagen so you can feel the benefits of cellular energy and cellular repair. Go to truniagen.com and use code MAX at checkout for $20 off any order of three months or more!

This episode is sponsored by my friends at Paleovalley. They make grass-fed beef sticks, superfood bars, and other carefully sourced, mindfully crafted, and nutrient-rich selections for optimal health! Go to Paleovalley.com/max for 15 percent off your entire order!

This episode is sponsored by my friends at ButcherBox, a meat delivery service that delivers grass-fed beef, free-range chicken, heritage pork, and wild-caught salmon. No antibiotics or added hormones, ever. Go to butcherbox.com/genius to get two pounds of wild-caught salmon for free in your first box!

This episode is sponsored by my friends at Public Goods, your one-stop shop for sustainable, high-quality, and affordable products that are good for people and the planet. Go to publicgoods.com/max and receive $15 off your first Public Goods order with no minimum purchase!

Resources from this episode:

Charles Brenner Lab | City of Hope

Charles Brenner | ChromaDex

Charles Brenner | Twitter

Nicotinamide Adenine Dinucleotide | Wikipedia

Nucleotide | National Human Genome Research Institute

The ATP Molecule | World of Molecules

NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide | FoundMyFitness

ATP and ADP | Northern Arizona University

Our Core Science - NAD+ and NADH: What's the Difference? | Elysium Health

NADP+ Definition and Function | Biology Dictionary

NADPH Definition and Function | Biology Dictionary

Why All Eyes Should be on NAD+, According to Scientists | Max Lugavere

NADPH Homeostasis in Cancer: Functions, Mechanisms, and Therapeutic Implications | Signal Transduction and Targeted Therapy

‪Donna L. Hammond‬ | ‪Google Scholar‬

Nicotinamide Riboside Relieves Paclitaxel-Induced Peripheral Neuropathy and Enhances Suppression of Tumor Growth in Tumor-Bearing Rats | Pain

9 Science-Based Benefits of Niacin (Vitamin B3) | Healthline

Vitamin B3: Niacin vs. Nicotinamide vs. Nicotinamide Riboside | Tru Niagen

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